Molecular Hydrogen Research – Metabolic Syndrome
Zhang, X., et al., Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes. J Diabetes Investig, 2018. 9(1): p. 83-90.
Korovljev, D., et al., Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Ir J Med Sci, 2017.
Hou, C., et al., Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer. Biochem Pharmacol, 2016. 103: p. 85-97.
Zong, C., et al., Cigarette smoke exposure impairs reverse cholesterol transport which can be minimized by treatment of hydrogen-saturated saline. Lipids Health Dis, 2015. 14: p. 159.
Song, G., et al., Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of Lipid Research, 2013. 54(7): p. 1884-93.
Jiang, H., et al., Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits advanced glycation end product-induced apoptosis. Int J Mol Med, 2013. 31(6): p. 1381-7.
Iio, A., et al., Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells. Medical Gas Research, 2013. 3(1): p. 6.
Ignacio, R.M., et al., Anti-obesity effect of alkaline reduced water in high fat-fed obese mice. Biol Pharm Bull, 2013. 36(7): p. 1052-9.
He, B., et al., Protection of oral hydrogen water as an antioxidant on pulmonary hypertension. Mol Biol Rep, 2013. 40(9): p. 5513-21.
Fan, M., et al., Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model. Journal of Urology, 2013. 190(1): p. 350-6.
Chen, Y., et al., Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways. International Journal of Molecular Medicine, 2013. 31(3): p. 597-606.
Amitani, H., et al., Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle. PLoS One, 2013. 8(1).
Zong, C., et al., Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters. Metabolism, 2012. 61(6): p. 794-800.
Zheng, H. and Y.S. Yu, Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats. Biochemical Pharmacology, 2012. 83(9): p. 1269-77.
Yu, Y.S. and H. Zheng, Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. Mol Cell Biochem, 2012. 365(1-2): p. 233-42.
Wang, Q.J., et al., Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress. Chin Med J (Engl), 2012. 125(9): p. 1633-7.
Tanabe, H., et al., Suppressive Effect of High Hydrogen Generating High Amylose Cornstarch on Subacute Hepatic Ischemia-reperfusion Injury in Rats. Biosci Microbiota Food Health, 2012. 31(4): p. 103-8.
Song, G., et al., Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice. Atherosclerosis, 2012. 221(1): p. 55-65.
Nishioka, S., et al., Effect of hydrogen gas inhalation on lipid metabolism and left ventricular remodeling induced by intermittent hypoxia in mice. European Heart Journal, 2012. 33: p. 794-794.
Kawai, D., et al., Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Hepatology, 2012. 56(3): p. 912-21.
Fan, M., et al., Protective Effects of Hydrogen-Rich Saline Against Erectile Dysfunction in a Streptozotocin Induced Diabetic Rat Model. J Urol, 2012.
Ekuni, D., et al., Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model. Arch Oral Biol, 2012. 57(12): p. 1615-22.
Yu, P., et al., Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. Biochemical and Biophysical Research Communications, 2011. 409(2): p. 350-5.
Yang, X., et al., Protective effects of hydrogen-rich saline in preeclampsia rat model. Placenta, 2011. 32(9): p. 681-6.
Wang, Y., et al., Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. Respir Res, 2011. 12: p. 26.
Song, G., et al., H2 inhibits TNF-alpha-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor kappaB activation in endothelial cells. Biotechnology Letters, 2011. 33(9): p. 1715-22.
Shirahata, S., et al., Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles. BMC Proc, 2011. 5 Suppl 8: p. P18.
Nakai, Y., et al., Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water. Bioscience, Biotechnology, and Biochemistry, 2011. 75(4): p. 774-6.
Li, Y., et al., Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology, 2011. 63(2): p. 119-31.
Kamimura, N., et al., Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice. Obesity, 2011.
Hashimoto, M., et al., Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat model. Medical Gas Research, 2011. 1(1): p. 26.
Nakao, A., et al., Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome-An Open Label Pilot Study. Journal of Clinical Biochemistry and Nutrition, 2010. 46(2): p. 140-149.
Chen, C.H., et al., Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation in a Focal Ischemia Rat Model. Neuroscience, 2010. 169(1): p. 402-414.
Abe, M., et al., Suppressive Effect of ERW on Lipid Peroxidation and Plasma Triglyceride Level, in Animal Cell Technology: Basic & Applied Aspects, S. Netherlands, Editor. 2010. p. 315-321.
Chao, Y.C. and M.T. Chiang, Effect of alkaline reduced water on erythrocyte oxidative status and plasma lipids of spontaneously hypertensive rats. Taiwanese Journal of Agricultural Chemistry and Food Science, 2009. 47(2): p. 71-72.
Ohsawa, I., et al., Consumption of hydrogen water prevents atherosclerosis in apoliporotein E knockout mice. Biochem Biophys Res Commun, 2008. 377(4): p. 1195-8.
Kajiyama, S., et al., Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research, 2008. 28: p. 137–143.
Kim, M.J., et al., Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice. Biol Pharm Bull, 2007. 30(2): p. 234-6.
Yeunhwa GU, K.O., Taigo FUj, Yuka ITOKAWA, et al., Anti Type 2 Diabetic Effect and Anti-oxidation Effect in Active Hydrogen Water Administration KK-Ay Mice. Medicine and Biology, 2006. 150(11): p. 384-392.
Kim, M.J. and H.K. Kim, Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice. Life Sci, 2006. 79(24): p. 2288-92.
Jin, D., et al., Anti-diabetic effect of alkaline-reduced water on OLETF rats. Biosci Biotechnol Biochem, 2006. 70(1): p. 31-7.
GU, H.Y., et al., Anti-oxidation Effect and Anti Type 2 Diabetic Effect in Active Hydrogen Water Medicine and Biology, 2006. 150(11): p. 384-392.
Dan, J., et al., Effect of mineral induced alkaline reduced water on sprague-dawley rats fed on a high fat diet. Exp. Biomed. Sci., 2006. 12: p. 1-7.
Li, Y.-P., Teruya, K., Katakura, Y., Kabayama, S., Otsubo, K.,Morisawa, S., et al, Effect of reduced water on the apoptotic cell death triggered by oxidative stress in pancreatic b HIT-T15 cell. Animal cell technology meets genomics, 2005: p. 121-124.
Kim, H.-W., Alkaline Reduced Water produced by UMQ showed Anti-cancer and Anti-diabetic effect. published online at http://www.korea-water.com/images/e_q.pdf 2004.
Hamaskai, T., et al., The suppressive effect of electrolyzed reduced water on lipid peroxidation. Animal Cell Technology: Basic & Applied Aspects, 2003. 13: p. 381-385.
Chiasson, J.L., et al., Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA, 2003. 290(4): p. 486-94.
Li, Y., et al., Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species. Cytotechnology, 2002. 40(1-3): p. 139-49.
Shirahata, S., Anti-oxidative water improves diabetes.
Oda, M., et al., Electrolyzed and natural reduced water exhibit insulin-like activity on glucose uptake into muscle cells and adipocytes. Animal Cell Technology: Products from Cells, Cells as Products, 2000: p. 425-427.
Nelson, D., et al., Effect of electrolyzed water intake on lifespan of autoimmune disease prone mice. Faseb Journal, 1998. 12(5): p. A794-A794.
Yokoyama, J.-m.K.a.K., Effects of alkaline ionized water on spontaneously diabetic GK-rats fed sucrose. J. of Lab. Anim Sa, 1997. 13(2): p. 187-190.
Darnaud, C., [Indications for alkaline mineral water cure in diabetes mellitus]. Toulouse Med, 1951. 52(5): p. 277-84.