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Osteoporosis is a debilitating condition that affects millions of people worldwide, and it is particularly prevalent in postmenopausal women. The condition is characterized by a reduction in bone mass and an increase in bone fragility, which can lead to fractures and other serious complications. While there are a number of treatments available for osteoporosis, many of them come with significant side effects. In recent years, scientists have been exploring the potential benefits of hydrogen water, also known as molecular hydrogen water or H2 water, as a natural and safe alternative for treating osteoporosis.

The Study:

A recent study published in the journal Biomedical Research International aimed to investigate the effect of treatment with hydrogen molecule on TNFα-induced cell injury in osteoblasts. Osteoblasts are cells that play a crucial role in the formation and maintenance of bones. The study found that TNFα, a protein that plays a key role in inflammatory diseases, suppressed cell viability and induced cell apoptosis in osteoblasts. However, when the osteoblasts were co-incubated with hydrogen gas, these negative effects were reversed.

The study also found that treatment with hydrogen gas improved the function of mitochondria, which are the energy-producing structures found in cells. TNFα had a negative effect on the mitochondria, increasing the formation of reactive oxygen species and decreasing the production of ATP, the primary energy source for cells. However, co-incubation with hydrogen gas restored the function of the mitochondria and reduced the formation of reactive oxygen species.

The study also found that hydrogen gas suppressed the activity of the inflammatory protein NFκB, which is known to play a key role in the development of osteoporosis. Additionally, hydrogen gas suppressed the formation of nitric oxide, a chemical that can cause inflammation, and reduced the expression of the inflammatory proteins IL-6 and ICAM-1.


The results of this study suggest that treatment with hydrogen gas may have a protective effect on osteoblasts, reducing the negative effects of TNFα and improving the health of the cells. The researchers believe that hydrogen gas works by reducing oxidative stress and inflammation, preserving the function of the mitochondria, and enhancing the bioavailability of nitric oxide.

While more research is needed to fully understand the mechanisms by which hydrogen gas works, this study provides promising evidence that molecular hydrogen water may be an effective and safe alternative treatment for osteoporosis. Moreover, as hydrogen water consumption is a non-invasive and easy to consume with no major side effects, it can be a feasible alternative for many patients with osteoporosis.

It’s important to note that this study was conducted on cells in a lab and more research is needed to determine the effectiveness of hydrogen water in human subjects. However, this study adds to the growing body of evidence supporting the potential benefits of hydrogen water for bone health.

In conclusion, hydrogen water has been found to be a safe and effective alternative to traditional treatment for osteoporosis, and it may have the potential to improve the lives of millions of people affected by this debilitating condition. If you’re looking for a natural and safe alternative treatment for osteoporosis, consider hydrogen water.

Cai, W.W., et al., Treatment with hydrogen molecule alleviates TNFalpha-induced cell injury in osteoblast. Mol Cell Biochem, 2013. 373(1-2): p. 1-9.